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The modern compatibility index for Steam games on Linux.

Steam · Linux · Proton & Native

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Protondex is an independent community compatibility index and is not affiliated with Valve, Steam, Proton, CodeWeavers, or ProtonDB.

Some historical compatibility records originate from ProtonDB's data export under the Open Database License (ODbL) v1.0; Protondex publishes a periodic public dump of its compatibility database under the same license. View the ODbL.

S.E.M.I. – Side Effects May Include... · Protondex

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S.E.M.I. – Side Effects May Include...

#3957560

S.E.M.I. is a single-player and co-op action platformer with puzzle elements. Play as patients of an unusual clinic, take experimental drugs, interfere with each other, and be ready for chaos and unpredictable side effects!

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Recommendation

ProtonGreat

Only Proton reports exist so far.

Compatibility

Proton

Great

✓CurrentLow confidence

2 reports · Low confidence: very few recent reports yet.

NativeNone

No native Linux build — Proton only

Desktop

Great

✓CurrentLow confidence

2 reports · Low confidence: very few recent reports yet.

HandheldUnknown

No reports yet

Anti-cheatUnknown

No anti-cheat reports yet

Summary based mostly on historical data from ProtonDB. Fresh reports from your setup help keep it current.

Freshness:✓Current2 reports · last updated Apr 9, 2026

Guide cards

No guide cards yet — curated troubleshooting for S.E.M.I. – Side Effects May Include... will appear here.

Reports (2)

PathOutcomeDeviceFreshnessAnti-cheat

2 of 2 reports

GreatProtonDesktopHistorical · ProtonDB
Apr 9, 2026
Imported from ProtonDB (ODbL)
BlockedProtonDesktopHistorical · ProtonDB
Sep 27, 2025
Imported from ProtonDB (ODbL)